RUNX transcription factors: orchestrators of development

Repression of CD4 in Thymocytes Transcription Factors Required for the Localization of the Domains in Runx

Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers

Transcription factors have traditionally been viewed with skepticism as viable drug targets, but they offer the potential for completely novel mechanisms of action that could more effectively address the stem cell like properties, such as self-renewal and chemo-resistance, that lead to the failure of traditional chemotherapy approaches. Core binding factor is a heterodimeric transcription facto...

Small Molecule Inhibitor of CBFbeta-RUNX Binding for RUNX Transcription Factor Driven Cancers

a r t i c l e i n f o Transcription factors have traditionally been viewed with skepticism as viable drug targets, but they offer the potential for completely novel mechanisms of action that could more effectively address the stem cell like properties , such as self-renewal and chemo-resistance, that lead to the failure of traditional chemotherapy approaches. Core binding factor is a heterodime...

Intranuclear Trafficking of RUNX/AML/CBFA/PEBP2 Transcription Factors in Living Cells: A Dissertation

The family of runt related transcription factors (RUNX/CbfaiAML/PEBP2) are essential for cellular differentiation and fetal development. RUNX factors are distrjbuted throughout the nucleus jn punctate focj that are assocjated with the nuclear matrix/scaffold and generally correspond with sjtes of active transcrjption. Truncations of RUNX proteins that eliminate the C-terminus including a 3l-ami...

Estrogen receptor coregulators and pioneer factors: the orchestrators of mammary gland cell fate and development

The steroid hormone, 17β-estradiol (E2), plays critical role in various cellular processes such as cell proliferation, differentiation, migration and apoptosis, and is essential for reproduction and mammary gland development. E2 actions are mediated by two classical nuclear hormone receptors, estrogen receptor α and β (ERs). The activity of ERs depends on the coordinated activity of ligand bind...